"After two weeks, I could finally wake up without dreading the day. My energy is steady, and I don't crash at 3pm anymore."
Adrenal Synergy
$39.49 — or subscribe and save up to 5%
- Comprehensive Support for immune system regulation and natural defense mechanisms
- Targeted enzymatic action that helps support systemic inflammation at its source
- Advanced formula that works throughout the entire body to support the break down of accumulated proteins
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Ingredients
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Per 2 Capsule Serving:
- Vitamin C (as ascorbic acid) - 100 mg
- Vitamin B6 (as pyridoxal-5-phosphate) - 10 mg
- Folate (as 5-methyltetrahydrofolate) - 200 mcg
- Zinc (as zinc glycinate) - 10 mg
- Rhodiola rosea root extract - 200 mg
- Ashwagandha root extract - 200 mg
- Deglycyrrhizinated licorice root - 150 mg
- Panax ginseng root extract - 100 mg
- Eleutherococcus senticosus root extract - 100 mg
- Glandular blend (pituitary, hypothalamus, thymus, adrenal) - 100 mg
Serving Size
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Label Information
- Contents: 60 capsules (30 servings)
- Serving Size: 2 capsules
- Dosing: Take 2 capsules daily with food or as directed by your healthcare professional
- Best taken: Morning with breakfast for optimal cortisol support
Warnings/Cautions
- Consult your healthcare provider before use if pregnant or nursing
- Not recommended for those with high blood pressure
- May interact with medications for diabetes or blood pressure
- Keep out of reach of children
- Store in a cool, dry place
Usage: Dietary Supplement
The Hidden Impact of Adrenal Stress
Understanding how deeply stress affects your entire body reveals why comprehensive adrenal support is essential:
Chronic stress depletes adrenal reserves, leading to fatigue, poor immunity and disrupted sleep[1]
Low cortisol patterns affect up to 30% of individuals with chronic stress and burnout[2]
Adrenal dysfunction impacts the HPA axis, affecting mood, energy, metabolism and inflammation[3]
Stress hormones directly influence brain chemistry and neurotransmitter function[4]
Nearly everyone dealing with modern stress needs adrenal support to thrive[5]
→ Your adrenals aren't just about stress—they're the foundation of your energy, immunity, and hormonal balance.
Top Benefits
Supports the Rebuilding of Depleted Reserves
Glandular extracts provide the raw materials your adrenals need to regenerate, while key nutrients support hormone production and energy pathways.
Supports the Balance of Stress Response
Adaptogenic herbs like rhodiola and ashwagandha help normalize cortisol rhythms—no more wired-but-tired or afternoon crashes.
Supports Mood & Mental Clarity
By addressing HPA axis dysfunction, many experience improved mood stability, better focus, and reduced anxiety.
Supports Physical Resilience
Panax ginseng and eleutherococcus help combat fatigue and support sustained energy without stimulants.
Supports Against Occasional Burnout
DGL licorice helps preserve cortisol levels, reducing the demand on already exhausted adrenals.
Who It's For
Adrenal Synergy Is Ideal For Those Experiencing:
- Chronic fatigue despite adequate sleep
- Feeling "wired but tired" or unable to relax
- Afternoon energy crashes
- Poor stress tolerance or quick to overwhelm
- Difficulty recovering from illness or exercise
See The Results Others Are Experiencing
"This formula brought me back from complete burnout. I feel like myself again—calm but energized."
"My patients with stubborn fatigue respond beautifully to this. It addresses the root cause, not just symptoms."
Key Ingredients
Rhodiola Rosea
Clinically shown to inhibit stress-induced cortisol spikes [1]
Ashwagandha
Modulates neurotransmitters and HPA axis activity [2]
DGL Licorice
Preserves cortisol and increases DHEA naturally [3]
Vitamin C, B6, Folate, Zinc
Essential cofactors for adrenal hormone synthesis [4]
Glandular Support
Pituitary, hypothalamus, thymus, and adrenal extracts [5]
Panax Ginseng & Eleutherococcus
Combat fatigue and support sustained energy [6]
What Makes Adrenal Synergy Different?
- Supports the entire HPA axis, not just adrenals
- Combines adaptogens, nutrients, and glandulars
- Supports rather than stimulates exhausted systems
- Based on clinical research, not trends
- Comprehensive support in one formula
The Science of Stress Resilience
This isn't another caffeine alternative—it's intelligent support that addresses the neuro-endocrine pathways depleted by chronic stress. Each ingredient works synergistically to support what stress has stolen.
Support What Stress Has Depleted
When your adrenals and HPA axis function properly, you feel the difference in every aspect of life—steady energy, balanced mood, better sleep, and the ability to handle whatever comes your way.
Because you weren't meant to run on empty.
Progressive Support
While some notice improved energy within days, Adrenal Synergy works progressively to support depleted reserves.
Suggested Use: Take 2 capsules daily with food or as directed by your healthcare professional.
For best results, take in the morning with breakfast.
For best results, take in the morning with breakfast.
By weeks 2-4 of consistent use, many report:
Supports steady energy throughout the day
Supports better stress tolerance
Mood and motivation support
Supports deeper, more restorative sleep
Support for recovery and resilience
HPA axis support that addresses root causes of adrenal fatigue
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Adrenal Synergy is a dietary supplement. Individual results may vary. Always consult with your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, have a medical condition, or are taking other medications.
Adrenal Synergy
$39.49 — or subscribe and save up to 5%
- Comprehensive Support for immune system regulation and natural defense mechanisms
- Targeted enzymatic action that helps support systemic inflammation at its source
- Advanced formula that works throughout the entire body to support the break down of accumulated proteins
Login
Login to purchase or request recommendation.
If you do not have a DesBio practitioner, click here.
References
- Edwards, D., Heufelder, A., & Zimmermann, A. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytotherapy Research, 26(8), 1220–1225.
- Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 11(12), e6466.
- Al-Dujaili, E. A., Kenyon, C. J., Nicol, M. R., & Mason, J. I. (2011). Liquorice and its potential therapeutic effects on the adrenal cortex: a brief review. Molecular and Cellular Endocrinology, 341(1-2), 1–6.
- Tardy, A. L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1), 228.
- Done, J. T., Anderson, P. H., & Hebert, C. N. (1966). Studies on the Aetiology of Scrapie: an assessment of the possibility of maternal transmission in the goat. Research in Veterinary Science, 7(4), 400-416.
- Panossian, A. G., & Wikman, G. (2009). Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular Mechanisms Related to their Stress-Protective Activity. Current Clinical Pharmacology, 4(3), 198–219.
- Wilson, J. L. (2001). Adrenal Fatigue: The 21st Century Stress Syndrome. Smart Publications.
- Fries, E., Hesse, J., Hellhammer, J., & Hellhammer, D. H. (2005). A new view on hypocortisolism. Psychoneuroendocrinology, 30(10), 1010–1016.
- Tsigos, C., & Chrousos, G. P. (2002). Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. Journal of Psychosomatic Research, 53(4), 865–871.
- Holsboer, F. (2000). The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology, 23(5), 477–501.